PersistIQ is a platform designed to streamline sales process automation and lead nurturing, while SalesHandy is an email tracking and automation platform. The main difference between the two is the scope of features and capabilities. PersistIQ focuses on helping salespeople to create automated sequences and mass communications, while SalesHandy focuses on tracking and managing email-related activities. PersistIQ provides advanced insights into leads and customer engagement, as well as the ability to build personalized sequences and respond to leads quickly. SalesHandy, on the other hand, specializes in tracking emails with built-in analytics and automation tools, such as auto follow-ups and scheduled messages. Both platforms provide powerful solutions for managing and nurturing leads, but they focus on different aspects of sales automation and offer unique capabilities.