ActiveCampaign is an email marketing automation and CRM software that helps you to create and effectively manage powerful, detailed campaigns. It provides automated segmentation of your contact list through tags and filters, advanced email personalization options, detailed automation and segmentation options, powerful email analytics, and integrates with hundreds of third-party applications.
Reply.io is an email marketing and sales automation platform that is focused on increasing sales. It helps you to personalize and automate your outbound sales and marketing activities to convert more leads into customers. Reply.io also provides features such as filtered lists, email automation, automated scoring and lead qualification, detailed analytics, and email template builder. Unlike ActiveCampaign, Reply.io does not offer CRM or segmentation capabilities.