The main difference between SalesLoft and LemList is in the features available. SalesLoft focuses on sales outreach activities like mass emailing and phone calling, while LemList focuses on email automation and helping with lead nurture. SalesLoft offers a more comprehensive suite of features, including sales automation, account-based marketing (ABM), analytics, and real-time sales insights. LemList has limited capabilities in comparison, and offers a simple campaign builder for email automation campaigns. Both tools offer similar pricing models, but LemList lacks the comprehensive feature set that SalesLoft does.