The primary difference between iContact and SalesLoft is in their purpose. iContact is an email marketing platform that helps businesses create, send, and manage email campaigns for their customers and prospects. SalesLoft is an email and sales automation platform that helps sales teams track emails and activities, set reminders, and monitor progress of sales opportunities. With iContact, users can design and track email campaigns, newsletters, surveys, and more. With SalesLoft, users have a wide range of features available, including email tracking, sales engagement, and automated sequences. Another key difference is that iContact is designed to operate with a 'set it and forget it' approach, while SalesLoft is designed to actively engage with prospects and customers to close deals.